The Mouse anti Plakophilin-3 Antibody from MyBioSource.com is a Mouse Monoclonal antibody to PKP3. This antibody recognizes Human, Mouse, Canine, and Porcine antigen. The Mouse anti Plakophilin-3 Antibody has been validated for the following applications: Immunocytochemistry, Immunohistochemistry, Immunohistochemistry - frozen, Immunoprecipitation, and Western Blot.
Description
Plakophilin-3 is an Armadillo-like protein present in nuclei and desmosomes of epithelial cells. The expression pattern of this protein seems to be largely restricted to epithelial cell types. Plakophilin-3 can be detected along cell borders in a punctuate staining pattern typical for desmosomal proteins. In addition to the desmosomal immunolocalisation, immunostaining was observed as bright nuclear speckles. Thus, like plakophilin-1 and-2, plakophilin-3 displays a dual intracellular localisation in the desmosomal plaque and in the cell nucleus, and therefore is probably involved in signal transduction pathways between the plasma membrane and the nucleus. The Human protein has a predicted molecular mass of 87 kD